Forskningsanslag

The primary cilium – a master regulator of beta-cell function in health and diabetes.

Characterizing the function of AUTS2 and ETV1 transcription factors in human pancreatic islet development and function.

The mechanisms of amino acids-regulated hormone release from pancreatic islets.

Paracrine control of islet hormone exocytosis in diabetes.

Novel selectively targeted stimulation of the β2-adrenoceptor for the treatment of type 2 diabetes.

Can we prevent adipocyte dysfunction and metabolic disease via metabolic targeting of the adipose tissue?

Roles of splice isoform CD59-IRIS-1 in beta-cell identity and function.

Stimulating β-cell regeneration as a novel treatment of diabetes.

Collagenous Peptides in the Regulation of Adipose Tissue Remodelling.

A randomized double-blind clinical trial comparing Hypochlorous Acid and Polyhexamethylene biguanide in treating diabetic foot ulcers.

Gastrointestinal adverse effects of metformin in treatment of type 2 diabetes - patients’ perspective and microbiota.

High resolution optical 3D imaging to understand human diabetes pathophysiology in a whole organ context.

Regulation of glucose homeostasis in type 2 diabetes by eicosanoids.

Studies of T2D disease mechanisms in human islets.

The inner ear as a target for insulin action-implications for diabetes complications.

The role of amp-activated protein kinase in the regulation of fatty acid synthesis in adipocytes.

The role of immune cell-microbial interactions for long-term islet function and glucose homeostasis.

Treat and prevent type 1 diabetes by mesenchymal stromal cells.

GPR44 as a PET marker for measuring beta cell mass in human.

Pathophysiologycaemia risk in insulin-treated diabetes patients:more than the sum of the parts? Typ 1 diabetes.

Rap and Ras signalling in insulin secretion.

Succinate-induced glucose uptake in skeletal muscle - a new therapeutic target for diabetes?

Enhancer landscape remodelling during macrophage metaflammatory activation and its involvement in obesity induced metabolic disorder

Induced endothelial expression of podocyte specific Retinoic acid receptor responder1 (Rarres1) in Diabetic Kidney Disease (DKD) accelerates renal injury

Subcutaneous adipogenesis is a marker of future risk of Type 2 Diabetes – role of endothelial and precursor cell senescence

The novel MafA target gene PPP1R1A is modulating the GLP1R-amplifying glucose-stimulated insulin secretion

Why do type-2 diabetic patients express less synaptotagmin 13 (SYT13) in their islets of Langerhans than healthy individuals?

CD36 as a therapeutic target to improve beta cell function in type 2 diabetes

Characerization of the diabetic pancreas to unravel the pathogenesis and etiology of type 1 diabetes

Diabetes associated vascular complications caused by impaired efferocytosis, inflammatory resolution and fibrotic tissue repair

Discovery and functional validation of regulatory networks in human pancreatic islets to identify targetable disease mechanisms underlying Type 2 diabetes

How many diseases are type 2 diabetes? Confirmation, evaluation and implementation of a new diabetes subclassification

Mechanisms in skin wound healing in non-diabetic and diabetic conditions and the effect of wound treatment with chemokines

Novel therapeutic tools and new biomarkers in diabetes with focus on islet specifik microRNAs

Refining Immunosuppression to Prevent Rejection of Porcine Islet Xenografts

Role of acetyltransferase GCN5 in endothelial oxidative stress in diabetes

Translational studies of insulinsecreting cells derived from induced pluripotent stem cells

Spring Point Project, its mission is to provide an unlimited source of pig islet cells to accelerate the availability and affordability of islet transplantation to cure diabetes

6000 steps for better health – a randomised 12-month intervention study

Autophagy in control of beta-cell mass and function in Type 2 Diabetes

Communication between virus-infected pancreatic beta-cells and the immune system: implication for Type 1 diabetes

Contribution of genes and non-coding RNAs expressed by Kupffer cells in insulin resistance

Determining the microbiota in subjects with prediabetes

Does Glycation of apoA-I links to higher risk of cardiovascular complications in diabetic patients?

In collaboration with Prof. PO Berggren, Karolinska Institutet: Evaluating vision in the baboon following pancreatic islet transplantation in the eye anterior chamber

Genetic and transcriptomic studies of fetal pancreas to understand fetal programming and development and identification of blood based biomarkers for pancreatic development

Growth differentiation factor 11 (GDF11) – a fons adolescentia for the pancreatic beta-cell that can delay or prevent onset of type 2 diabetes?

Molecular control over a neuronal circuit that mediates feeding behaviour – and important new target in the fight against diabetes

Refining Immunosuppression to Prevent Rejection of Porcine Islet Xenografts

Short chain fatty acids; gut metabolites with implications for metabolic health

The importance of endothelial and red blood cell dysfunction for vascular complications in type 2 diabetes

The role of the duodenal microbiota in the etiopathology of Type 1 Diabetes

Spring Point Project, its mission is to provide an unlimited source of pig islet cells to accelerate the availability and affordability of islet transplantation to cure diabetes

An in vivo approach to understand inositide signalling in the pancreatic beta cell

Betydelsen av budbärarämnet cAMP för reglering av insulin- och glukagonfrisättningen

Cellular interactions of mesenchymal stromal cells in type 1 diabetes

Correlation between systemic insulin resistance and bimodal adipose cell response

En ny unik medicinsk behandling av typ-2 diabetes baserat på hämmandet av proteinkinaset STK25

Hur påverkar fetma och typ 2 diabetes muskelstamcellernas funktion?

Novel strategies for treating diabetes

The role of pancreatic macrophages for development and maturation of islets of Langerhans and long-term metabolic control

Tissue factor signaling in islets and beta-cells

Träningsintervention vid metabola sjukdomar

Typ 2 diabetes: en betacellsdegenerativ sjukdom?

Understanding redox signalling in diabetic cardiomyopathy: role of AP-1 transcription factor JunD

Vilken påverkan har ärftlighet på muskelegenskaper och metabolsjukdom? - funktionen av RAB3GAP2 och MAOA

Assembly of the insulin granule secretory machinery

Can high concentrations of IAPP in plasma indicate the formation of beta-cell toxic species?

Dissecting the role of mitochondrial dysfunction in pancreatic beta-cells in Type 2 Diabetes

Does brusatol counteract high-fat diet-induced glucose intolerance in mice?

Expansion of pancreatic islets in vitro and transplantation treatment in diabetic mice

Gastric bypass surgery as a model for identification of new treatments for Type 2 Diabetes

Mechanisms underlying 'browning' of white adipose tissue

Myeloid-derived suppressor cells for tolerance to islet transplants

Neural control of the endocrine pancreas - from molecular pathways to human physiology in health and disease

Novel approaches for monitoring of endogenous ?-cells

Quantitate imaging as a tool to characterize the ongoing pathophysiology in children with recent onset type 1 diabetes

Targeted exercise intervention in the prevention of metabolic disease

The gamma-4 subunit of voltage-gated calcium ion channels (CaV?4) is an effector of beta-cell dedifferentiation in type 2 diabetes and a potential target for disease-modifying treatment

The role of arginase as a novel therapeutic target to improve cardiovascular function in type 2 diabetes

Transplantation of human islets in oxygenated macrocapsules to patients with type 1 diabetes mellitus